FITC标记的磷酸化信号转导和转录激活因子6抗体
产品名称： FITC标记的磷酸化信号转导和转录激活因子6抗体
英文名称： Anti-phospho-STAT6 (Tyr641)/FITC
产品编号： HZ-1791R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-phospho-STAT6 (Tyr641)/FITC Conjugated antibody
FITC标记的磷酸化信号转导和转录激活因子6抗体
| 英文名称 | Anti-phospho-STAT6 (Tyr641)/FITC |
| 中文名称 | FITC标记的磷酸化信号转导和转录激活因子6抗体 |
| 别 名 | STAT6 (phospho Y641); p-STAT6 (phospho Y641); STAT6(Phospho-Tyr641); D12S1644 IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 细胞生物 神经生物学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 94kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human STAT6 around the phosphorylation site of tyrosine Tyr641 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Also known as: signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT. Function: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling. Subunit: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif. Subcellular Location: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. Post-translational modifications: Tyrosine phosphorylated following stimulation by IL-4 and IL-3. Similarity: Belongs to the transcription factor STAT family. Contains 1 SH2 domain. Database links: Entrez Gene: 6778 Human Entrez Gene: 20852 Mouse Entrez Gene: 362896 Rat Omim: 601512 Human SwissProt: P42226 Human SwissProt: P52633 Mouse Unigene: 524518 Human Unigene: 121721 Mouse Unigene: 6880 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 转录调节因子（Transcriptin Regulators） |
由该基因编码的蛋白质是STAT家族转录因子的成员。作为对细胞因子和生长因子的响应，STAT家族成员被受体相关激酶磷酸化，然后形成同源或异源二聚体，这些同源或异源二聚体迁移到细胞核，在那里它们充当转录激活剂。这种蛋白在施加IL4介导的生物反应中起着中心作用。发现bcl 2L1/bcl－x（L）的表达可诱导IL4的抗凋亡活性。在小鼠中进行敲除研究表明该基因在T辅助细胞2（Th2）的分化、细胞表面标志物的表达和免疫球蛋白的分类转换中的作用。又称：信号转导和激活子6；D12S1644；IL4 STAT；IL4 STAT；白细胞介素4诱导的；白细胞介素4诱导的转录因子IL4 STAT；信号转导和激活子6；白细胞介素4诱导的；信号转导和激活子6NIRS变异体1；STAT 6；STAT6白细胞介素4诱导；STAT6B；STAT6C；转录因子IL 4 STAT.